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specializing in addiction recovery CLINICAL DRUG TESTING

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25 Airpark Court Greenville, SC 29607

877.930.3390

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About Us

Urine & Saliva Drug Testing - Pharmacogenetics

• Extended drug testing panels cover drugs of abuse, psychotherapeutics, and emerging drugs, allowing physicians to see the full scope of drug use by their patients and evaluate possible drug interactions, as poly- pharmacy is the largest contributor to drug related deaths. • Toxicology Reporting is easy to understand and provides relevant comments for physicians to help with results interpretation. • Toxicologists are easily accessed by phone and routinely work closely with our provider clients to answer questions and assist with toxicology reporting results interpretation. • Standard turn-around time for toxicology reporting is 24 hours to 36 hours, once the specimen has been delivered to our laboratory. • Committed to maintaining the highest level of Toxicology Reporting to the providers we serve, including Addiction Medicine, Hospitals, Pain Management, and Behavioral Health.

LabSource provides High Sensitivity Definitive Toxicology testing services utilizing LC-MS/MS. Our goal is to provide our physician clients with the greatest drug detection window possible while maintaining flawless specificity of testing to ensure accuracy.

We Invite You To Experience The LabSource Difference

Through the use of our proprietary specimen preparation process, we are able to achieve some of the lowest reportable limits (cut-offs) in the clinical toxicology testing industry for opioid / opiate and benzodiazepine drug classes. Perceived non- compliance can have very negative consequences for a patient, including being discharged from an Addiction Recovery program or being falsely accused of misuse or diversion of a prescribed pain management medication.

Did you know over 1/3 of commonly prescribed medications

are not detected by immunoassay

25 AIRPARK COURT • GREENVILLE, SC 29607 877.930.3390 WWW.LABSOURCE.NET CONTACT US TODAY

Hospitals and healthcare systems are being charged with the health and wellness of the community of patients they serve. Over the past decade, hospitals have actively acquired physician practices and

Successful Hospital Management of CPDs includes: • Cost Containment through Better Management of CPD Use in Your Patient Population • Better Patient Outcomes with High Sensitivity Definitive Toxicology Testing • Pharmacogenetics Testing for Effective CPD Treatment • Rapid ROI with our Hospital Client Bill Program • Increase Hospital Revenue by Capturing Outsourced Revenue How can Hospitals Use Pharmacogenetics to Improve Patients’ Outcomes? • Proactively Address a Patient’s Poor Therapeutic Response to an Opioid, Benzodiazepine, or Antidepressant Treatment • Evaluate Genetic Pathways in Patients with a History of Allergic or Adverse Reactions to Medications • Evaluate Prescription Treatment Options for Patients with a History of Substance Abuse and Relapse • Collect Additional Data Points for Patients with Unusual Toxicology Results (i.e. drug metabolites not present)

have moved towards a population health

management model with the goal of reducing costs while improving patient care and outcomes.

As a consequence of hospitals building their provider networks through acquisition, they have also assumed risk in the management of CPDs for their patient population. CPDs include opioids, benzodiazepines, amphetamines, stimulants, muscle relaxers, and sleep aids. CPDs can be effectively monitored for misuse, abuse, and diversion with a comprehensive medication monitoring protocol utilizing high sensitivity definitive toxicology testing. LabSource works closely with hospital clients delivering an effective medication monitoring protocol through Risk Stratification models, pharmacogenetics and the latest in toxicology testing methodology to help hospitals and providers quickly recognize potential misuse, abuse, and diversion of CPDs, as well as testing for illicit drug use. Utilizing a dedicated clinical toxicology laboratory as a part of your medication monitoring protocol will deliver to your providers consistent and comprehensive toxicology reporting. The LabSource Science Leadership team has extensive experience working in the hospital environment and can provide research support, payer support, hospital client bill, in-sourcing toxicology laboratory development, and EMR & LIS interfaces. LabSource works closely with hospital clients delivering an effective medication monitoring

ACCURATE RESULTS

URINE DRUG TEST

Clinical toxicology testing using a urine specimen is the preferred method to detect more remote drug use as drug and drug metabolites can be detected over a greater detection window.

Contact Us (877)930-3390 25 Airpark Court Greenville, SC 29607

FOR MORE INFORMATION PLEASE VISIT OUR WEBSITE AT WWW.LABSOURCE.NET

Contact Us 877.930.3390 25 Airpark Court Greenville, SC 29607 LABSOURCE.NET

HIGH SENSITIVITY DEFINITIVE TOXICOLOGY TESTING

Synthetic Cannabinoids are a much more common drug of abuse today

Emerging Drugs of Abuse New and Emerging Drugs of Abuse, both illicit drugs and prescription medications, continuously enter the market causing demand for larger test panels to ensure patient recovery compliance. Synthetic Cannabinoids are a much more common drug of abuse today, in part caused by the ease of access to these illicit drugs. It is important to test for all potential drugs of abuse ensuring a patient’s safety and compliance during the critical early stages of recovery. LabSource recognizes and meets physicians’ needs for current and highly accurate comprehensive toxicology testing results, along with meeting the need for rapid turn-around times for Addiction Medicine, Medication Assisted Therapy, and Intensive Outpatient Programs. LabSource continually monitors the pulse of drug abuse trends to keep pace with the emerging drugs of abuse market. Synthetic designer drugs, like synthetic cannabinoids, cathinones, and phenethylamines, have grown in popularity based on the addictive properties and ease of access to these drugs. Testing for these drugs of abuse can ensure addiction recovery patients are remaining compliant with their treatment.

Extensive Drugs of Abuse Testing

Urine Drug Testing is an integral part of addiction medicine recovery by providing definitive evidence of patient compliance while removing the doubts of potential diversion. Definitive drug testing gives providers the resources to make patients accountable and can help enforce program compliance which supports better patient outcomes. Confirmatory testing using LC-MS/MS technology provides definitive patient testing results that are not found using Immunoassay Analyzer testing or Point-of-Care cups. Are you missing 10% to 15%* of your Patients’ Positive Opioid Test Results? You may be without High Sensitivity Definitive Testing.

www.labsource.net

CALL US TODAY! 877.930.3390 25 Airpark Court Greenville, SC 29607

SAMHSA PUBLISHES BEST PRACTICES ON MEDICATION-ASSISTED TREATMENT FOR OPIOID USE DISORDER Best Practices

Treatment Improvement Protocol 63, “Medications for Opioid Use Disorder,”

reviews the use of methadone, naltrexone, and

buprenorphine, the three FDA-approved medications to treat opioid use disorders.

Data indicate that OUD-treating medications are both cost effective and cost beneficial

The Substance Abuse and Mental Health Services Administration has published new guidance to help health care professionals better understand medications that can be used to treat Americans with opioid use disorder (OUD). Treatment Improvement Protocol (TIP) 63, “Medications for Opioid Use Disorder,” reviews the use of methadone, naltrexone, and buprenorphine, the three FDA-approved medications to treat opioid use disorders. TIP 63 provides guidance for health care professionals and addiction treatment providers on how to appropriately prescribe these medications and effectively support patients using these medications for OUD treatment. “We know that people can and do recover from opioid use disorders when they receive appropriate treatment, and medication-assisted treatment’s success in treating opioid use disorders is well documented,” said Dr. Elinore F. McCance-Katz, assistant secretary for Mental Health and Substance Use. “TIP 63 emphasizes that increasing access to medications to treat opioid use disorder will help more people recover, enabling them to improve their health, living full and productive lives.” TIP 63 is part of SAMHSA’s larger response to the opioid crisis. More access to treatment with OUD medications is critical to closing the gap between treatment need and treatment availability and an important public health strategy. Data indicate that OUD-treating medications are both cost effective and cost beneficial.

CALL US TODAY! 877-930-3390

Our goal is to provide our physician clients with the greatest drug detection window possible while maintaining flawless specificity of testing to ensure accuracy.

25 AIRPARK COURT • GREENVILLE, SC 29607 | WWW.LABSOURCE.NET

LabSource provides High Sensitivity Definitive

Toxicology testing services utilizing LC-MS/MS.

25 AIRPARK COURT • GREENVILLE, SC 29607 PH: (877)930-3390 | LABSOURCE.NET

support and self-help strategies. The use of high sensitivity definitive urine drug testing can confirm treatment compliance while the use of large toxicology testing panels can ensure patients are not continuing to self-medicate with alternative drugs of abuse. LabSource offers extensive Psychotherapeutics Definitive Testing on over 30 brand names of antidepressants (SSRI, SNRI, Tricyclic, and other antidepressants). Testing patients for prescribed psychotherapeutic medications can ensure the patient is compliant with their treatment plan as well as providing piece of mind for the prescriber.

Behavioral health problems often times lead to alcohol and substance abuse as an attempt to self-medicate. Typically, as alcohol and substance abuse increases, the ability for a patient to manage their mental health problems will decrease. Behavioral health patients who are taking prescribed medications such as antidepressants, anti-anxiety medications, or mood stabilizers when combined with alcohol or drugs of abuse will diminish the effects of the prescribed medications, or even worse, the combined effect may cause death. Patients with mental health problems, who also abuse alcohol and drugs, a co-occurring disorder or dual-diagnosis, require medical treatment for both issues. Medication assisted treatments may include Suboxone (Buprenorphine), Naloxone or Vivitrol treatment along with counseling, group

• EXTENSIVE PANEL OF PRESCRIPTION & ILLICIT DRUGS OF ABUSE • ALCOHOL TESTING – ETHANOL METABOLITES ETG / ETS • BENZODIAZEPINES • SSRI & SNRI ANTIDEPRESSANTS • TRICYCLIC ANTIDEPRESSANTS • DEFINITIVE URINE DRUG TESTING & SALIVA DRUG TESTING MEETING THE DRUG TESTING NEEDS OF BEHAVIORAL HEALTH SPECIALISTS & PSYCHIATRISTS WITH HIGH SENSITIVITY DEFINITIVE TOXICOLOGY TESTING:

LABSOURCE IS ABOUT CHANGING PEOPLE’S LIVES

25 AIRPARK COURT • GREENVILLE, SC 29607 877.930.3390 WWW.LABSOURCE.COM CONTACT US TODAY

Researcher highlights ten main problems that must be addressed to modernize toxicology MODERNIZING Toxicology

“To meet the challenges of the 21st century, revolution rather than evolution is required.”

Toxicology as a science has not evolved to keep pace with the chemical revolution, according to Thomas Hartung writing in the International Journal of Risk Assessment and Management, Hartung highlights ten problems that must be addressed if toxicology is to be made fit for purpose in the 21st Century. Until the industrial revolution almost the complete gamut of poisons and toxins lay in the natural realm. Lethal alkaloids from toxic plants, arsenic-containing rocks, noxious fumes from fires and plenty of other sources of risk. It wasn’t until the Industrial Revolution and the maturation of alchemy to chemistry, that synthetic chemicals became an issue. In the 19th and 20th century, chemists identified literally tens of millions more chemicals in nature and in their laboratories and turned what was essentially a world of arsenic and old lace into the vast chemical space of toxicity we know, but cannot comprehend fully today.

According to Hartung of the Center for Alternatives to Animal Testing at Johns Hopkins Bloomberg School of Public Health, in Baltimore, Maryland, USA and also of the University of Konstanz, Germany, there are ten main issues to be addressed in modernising toxicology:

1. The disparity of testing requirements and risk acceptance for different products and geographical areas 2. Throughput and costs of testing versus testing needs 3. Limited predictivity for humans 4. Precautionary approaches from drug development adapted to other areas 5. Animal use 6. New products not suitable for traditional tests 7. New hazards not covered 8. Mixtures of toxicants not addressed 9. Individual susceptibilities and vulnerable subpopulations not covered 10. Poor basic research and publication standards

Hartung concedes that it is relatively easy to criticise and yet the issues seem obvious in his analysis and that change is needed. He suggests that given the intransigence in the world of international toxicological policies and methods this overarching issue must be overcome first before these ten issues can be addressed. “While current approaches are still needed, there is room for substantial change,” he says. “To meet the challenges of the 21st century, revolution rather than evolution is required.”

When you hear the term “drug testing”, you would be forgiven if the first thing that comes to mind is urine sample. This is especially true when the media is full of stories about athletes failing drug tests, plans to drug test welfare recipients and even the selling of fake urine to pass drug tests. Urine samples are the gold standard (excuse the colour reference), when it comes to drug testing based on a long and comprehensive experience. However it is not without its fair share of problems. These include spiking, swapping or even privacy concerns when it comes to sample collection supervision. HOLD YOUR BREATH Drug testing just got more advanced

First fully validated method of detecting drugs of abuse in exhaled breath

Other specimens in drug testing include blood, hair, sweat and even oral fluid (saliva). Blood has the obvious disadvantage of requiring trained personnel to take the sample, not to mention that it is far more intrusive for the donor. Drug testing on oral fluid (saliva) is well documented and will even become an integral part of a new drug drive legislation that is coming into force on the 2nd of March 2015 in the UK. Now imagine taking this one step further, and having your exhaled breath analysed for drugs? Ever since their unexpected discovery of Amphetamines in exhaled breath several years ago, scientists at the Karolinska Institutet in Sweden have continued to push the barriers in this method of drug testing. In their latest paper, published in Elsevier’s Journal of Chromatography B, Professor Olof Beck and his team have successfully developed the first fully validated and robust screening method suitable for the routine measurement of drugs of abuse in exhaled breath, with a simple procedure for specimen collection sample preparation. This was followed by a highly sensitive analytical technique known as LC-MS (Liquid chromatography– mass spectrometry). The drugs of abuse identified include: amphetamines, methamphetamines, cannabis, cocaine and heroin. Every Breath you... Exhale

Professor Olof Beck from Karolinska institutet, Sweden explains how this is possible: “The underlying mechanism in exhaled breath drug testing is believed to be the formation of aerosol particles from the airway lining fluid by the breathing process. These aerosol particles may become contaminated with drugs present in the body, which enables drug testing using this specimen. A simple collection device is currently available which selectively collects the micrometer aerosol particles on a filter and enables further laboratory investigation of possible drug content.” When asked if he could foresee this method of drug testing being used routinely for example in roadside tests relating to DUID (Driving Under the Influence of Drugs), Professor Beck added: “Yes, I see many possible applications of breath drug testing. DUID is only one - workplace, criminal justice, accidents and compliance monitoring of patients are others. For DUID the short detection time is relevant since the state of influence is in focus, and this combined with the convenient sampling procedure makes it an attractive solution for roadside testing.”

25 AIRPARK COURT • GREENVILLE, SC 29607 877.930.3390 WWW.LABSOURCE.NET CONTACT US TODAY

OUR GOAL IS TO PROVIDE OUR PHYSICIAN CLIENTS WITH THE GREATEST DRUG DETECTIONWINDOW POSSIBLE WHILE MAINTAINING FLAWLESS SPECIFICITY OF TESTING TO ENSURE ACCURACY.

25 AIRPARK COURT • GREENVILLE, SC 29607 | LABSOURCE.NET 877.930.3390

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